Our Publications
2026
Mutant KRAS Heterogeneity Shapes Nuclear Architecture During Pancreatic Cancer Initiation
Epigenomes
·
10 Mar 2026
·
doi:10.3390/epigenomes10010019
2025
Transcriptional drivers and endocrine disorders
Endocrine Connections
·
01 Oct 2025
·
doi:10.1530/EC-25-0688
Genomic features of the methylosome protein MEP50 and its implications in hormone signaling and cancer
Endocrine Connections
·
01 Sep 2025
·
doi:10.1530/EC-25-0444
KRAS inhibition reverses chemotherapy resistance promoted by therapy-induced senescence-like in pancreatic ductal adenocarcinoma
Translational Oncology
·
01 Jul 2025
·
doi:10.1016/j.tranon.2025.102421
2024
Emergent properties of the lysine methylome reveal regulatory roles via protein interactions and histone mimicry
Epigenomics
·
05 Dec 2024
·
doi:10.1080/17501911.2024.2435244
The triple code model for advancing research in rare and undiagnosed diseases beyond the base pairs
Epigenomics
·
04 Dec 2024
·
doi:10.1080/17501911.2024.2436837
EHMT2 Inactivation in Pancreatic Epithelial Cells Shapes the Transcriptional Landscape and Inflammation Response of the Whole Pancreas
openRxiv
·
16 Mar 2024
·
doi:10.1101/2024.03.14.584700
Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors
EMBO Molecular Medicine
·
15 Feb 2024
·
doi:10.1038/s44321-024-00032-2
2023
Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction
Frontiers in Genetics
·
28 Nov 2023
·
doi:10.3389/fgene.2023.1291307
Writers and readers of H3K9me2 form distinct protein networks during the cell cycle that include candidates for H3K9 mimicry
Bioscience Reports
·
01 Oct 2023
·
doi:10.1042/BSR20231093
EZH2 deletion does not impact acinar cell regeneration but restricts progression to pancreatic cancer in mice
openRxiv
·
28 Sep 2023
·
doi:10.1101/2023.09.25.559339
A Multi-Layered Computational Structural Genomics Approach Enhances Domain-Specific Interpretation of Kleefstra Syndrome Variants in EHMT1
openRxiv
·
07 Sep 2023
·
doi:10.1101/2023.09.06.556558
Priming therapy by targeting enhancer-initiated pathways in patient-derived pancreatic cancer cells
eBioMedicine
·
01 Jun 2023
·
doi:10.1016/j.ebiom.2023.104602
Overlapping and Distinct Functions of an Extended Repertoire of KRAS Mutations
Springer Science and Business Media LLC
·
08 May 2023
·
doi:10.21203/rs.3.rs-2883088/v1
KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress
Cell Death & Disease
·
02 May 2023
·
doi:10.1038/s41419-023-05731-1
Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape
openRxiv
·
28 Apr 2023
·
doi:10.1101/2023.04.28.536249
G9a Modulates Lipid Metabolism in CD4 T Cells to Regulate Intestinal Inflammation
Gastroenterology
·
01 Feb 2023
·
doi:10.1053/j.gastro.2022.10.011
Effects of Subnormothermic Regulated Hepatic Reperfusion on Mitochondrial and Transcriptomic Profiles in a Porcine Model
Annals of Surgery
·
10 Jan 2023
·
doi:10.1097/SLA.0000000000005156
Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape
Computational and Structural Biotechnology Journal
·
01 Jan 2023
·
doi:10.1016/j.csbj.2023.10.003
A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1
Computational and Structural Biotechnology Journal
·
01 Jan 2023
·
doi:10.1016/j.csbj.2023.10.022
2022
KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress
Springer Science and Business Media LLC
·
16 Sep 2022
·
doi:10.21203/rs.3.rs-2003235/v1
Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction
npj Precision Oncology
·
17 Aug 2022
·
doi:10.1038/s41698-022-00299-z
NUPR1 protects against hyperPARylation-dependent cell death
Communications Biology
·
22 Jul 2022
·
doi:10.1038/s42003-022-03705-1
Adapting Mentoring in Times of Crisis: What We Learned from COVID-19
Academic Psychiatry
·
25 Feb 2022
·
doi:10.1007/s40596-022-01589-1
Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers
Computational and Structural Biotechnology Journal
·
01 Jan 2022
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doi:10.1016/j.csbj.2022.04.028
2021
Collateral Victim or Rescue Worker?—The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer
Frontiers in Cell and Developmental Biology
·
16 Nov 2021
·
doi:10.3389/fcell.2021.735107
Precision medicine in trauma: a transformational frontier in patient care, education, and research
European Journal of Trauma and Emergency Surgery
·
16 Nov 2021
·
doi:10.1007/s00068-021-01817-7
KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells
Genome Biology
·
14 Oct 2021
·
doi:10.1186/s13059-021-02498-6
Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1‐like (
DOT1L
) and partnering complexes involved in leukemogenesis
Proteins: Structure, Function, and Bioinformatics
·
12 Sep 2021
·
doi:10.1002/prot.26219
New Insights Into Pancreatic Cancer: Notes from a Virtual Meeting
Gastroenterology
·
01 Sep 2021
·
doi:10.1053/j.gastro.2021.04.082
Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks
Frontiers in Cell and Developmental Biology
·
23 Jun 2021
·
doi:10.3389/fcell.2021.681153
Correction to: Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction
Orphanet Journal of Rare Diseases
·
01 Jun 2021
·
doi:10.1186/s13023-021-01892-4
Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer
EMBO Molecular Medicine
·
07 May 2021
·
doi:10.15252/emmm.202114243
A GATA6-centred gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer
Gut
·
12 Apr 2021
·
doi:10.1136/gutjnl-2020-321397
Metabolomic profiling of pancreatic adenocarcinoma reveals key features driving clinical outcome and drug resistance
eBioMedicine
·
01 Apr 2021
·
doi:10.1016/j.ebiom.2021.103332
Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level
Frontiers in Oncology
·
05 Mar 2021
·
doi:10.3389/fonc.2021.606820
Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction
Orphanet Journal of Rare Diseases
·
05 Feb 2021
·
doi:10.1186/s13023-021-01692-w
Metabolomic profiling of pancreatic adenocarcinoma reveals fundamental clinical features
openRxiv
·
02 Feb 2021
·
doi:10.1101/2021.02.01.429087
Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells
Science Advances
·
29 Jan 2021
·
doi:10.1126/sciadv.abe3445
2020
Variant anatomy of the biliary system as a cause of pancreatic and peri-ampullary cancers
HPB
·
01 Dec 2020
·
doi:10.1016/j.hpb.2020.03.014
ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents
JCI Insight
·
17 Sep 2020
·
doi:10.1172/JCI.INSIGHT.138117
A GATA6-centered gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer
openRxiv
·
09 Apr 2020
·
doi:10.1101/2020.04.09.033456
Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse
Molecular Cancer Research
·
01 Mar 2020
·
doi:10.1158/1541-7786.MCR-19-0490
Discovery, expression, cellular localization, and molecular properties of a novel, alternative spliced HP1γ isoform, lacking the chromoshadow domain
PLOS ONE
·
06 Feb 2020
·
doi:10.1371/journal.pone.0217452
2019
Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma
Cells
·
17 Nov 2019
·
doi:10.3390/cells8111453
Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine
Nature Communications
·
28 Aug 2019
·
doi:10.1038/s41467-019-11812-7
CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis
JCI Insight
·
20 Jun 2019
·
doi:10.1172/jci.insight.127111
Modeling post‐translational modifications and cancer‐associated mutations that impact the heterochromatin protein 1α‐importin α heterodimers
Proteins: Structure, Function, and Bioinformatics
·
14 Jun 2019
·
doi:10.1002/prot.25752
Aurora kinase B-phosphorylated HP1α functions in chromosomal instability
Cell Cycle
·
26 May 2019
·
doi:10.1080/15384101.2019.1618126
Discovery, Expression, Cellular Localization, and Molecular Properties of a Novel, Alternative Spliced HP1γ Isoform, Lacking the Chromoshadow Domain
openRxiv
·
14 May 2019
·
doi:10.1101/638395
The New Bench for the Academic Surgeon: Precision Medicine
Management of Localized Pancreatic Cancer
·
01 Jan 2019
·
doi:10.1007/978-3-319-98944-0_16
Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis
Cellular and Molecular Gastroenterology and Hepatology
·
01 Jan 2019
·
doi:10.1016/j.jcmgh.2018.09.005
Disruption of FOXP3–EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation
Cellular and Molecular Gastroenterology and Hepatology
·
01 Jan 2019
·
doi:10.1016/j.jcmgh.2018.08.009
2018
Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis
Scientific Reports
·
19 Nov 2018
·
doi:10.1038/s41598-018-35020-3
Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway
Scientific Reports
·
10 Oct 2018
·
doi:10.1038/s41598-018-33475-y
Co-occurrence of a maternally inherited DNMT3A duplication and a paternally inherited pathogenic variant in EZH2 in a child with growth retardation and severe short stature: atypical Weaver syndrome or evidence of a DNMT3A dosage effect?
Molecular Case Studies
·
25 May 2018
·
doi:10.1101/mcs.a002899
Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes
Nature Communications
·
17 May 2018
·
doi:10.1038/s41467-018-04383-6
Epigenetics of gastrointestinal diseases: notes from a workshop
Epigenetics
·
03 Apr 2018
·
doi:10.1080/15592294.2018.1464351
Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis
openRxiv
·
06 Mar 2018
·
doi:10.1101/277384
EGFR (ErbB) Signaling Pathways in Pancreatic Cancer Pathogenesis
Pancreatic Cancer
·
01 Jan 2018
·
doi:10.1007/978-1-4939-7193-0_15
2017
Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms
JCI Insight
·
21 Dec 2017
·
doi:10.1172/jci.insight.92821
LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth
F1000Research
·
16 Nov 2017
·
doi:10.12688/f1000research.12169.1
Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts
Cell Reports
·
01 Nov 2017
·
doi:10.1016/j.celrep.2017.11.003
Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe
Molecular Cancer Research
·
01 Aug 2017
·
doi:10.1158/1541-7786.MCR-17-0063
Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss
Frontiers in Cellular Neuroscience
·
07 Jul 2017
·
doi:10.3389/fncel.2017.00192
Functional validation reveals the novel missense V419L variant in TGFBR2 associated with Loeys–Dietz syndrome (LDS) impairs canonical TGF-β signaling
Molecular Case Studies
·
14 Apr 2017
·
doi:10.1101/mcs.a001727
Gene expression profiling of patient‐derived pancreatic cancer xenografts predicts sensitivity to the
BET
bromodomain inhibitor
JQ
1: implications for individualized medicine efforts
EMBO Molecular Medicine
·
08 Mar 2017
·
doi:10.15252/emmm.201606975
A Novel Kleefstra Syndrome-associated Variant That Affects the Conserved TPLX Motif within the Ankyrin Repeat of EHMT1 Leads to Abnormal Protein Folding
Journal of Biological Chemistry
·
01 Mar 2017
·
doi:10.1074/jbc.M116.770545
A novel de novo frameshift deletion in EHMT 1 in a patient with Kleefstra Syndrome results in decreased H3K9 dimethylation
Molecular Genetics & Genomic Medicine
·
26 Jan 2017
·
doi:10.1002/mgg3.268
2016
Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion
PLOS ONE
·
09 Dec 2016
·
doi:10.1371/journal.pone.0168266
The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes KrasG12D-mediated pancreatic cancer initiation
Cell Death & Disease
·
14 Jul 2016
·
doi:10.1038/cddis.2016.202
The Promise of Epigenomic Therapeutics in Pancreatic Cancer
Epigenomics
·
01 Jun 2016
·
doi:10.2217/epi-2015-0016
REG3β Plays a Key Role in IL17RA Protumoral Effect—Response
Cancer Research
·
31 Mar 2016
·
doi:10.1158/0008-5472.CAN-15-3355
Pharmacological and Therapeutic Targeting of Epigenetic Regulators
Chromatin Signaling and Diseases
·
01 Jan 2016
·
doi:10.1016/B978-0-12-802389-1.00021-6
2015
Evidence supporting a critical contribution of intrinsically disordered regions to the biochemical behavior of full-length human HP1γ
Journal of Molecular Modeling
·
17 Dec 2015
·
doi:10.1007/s00894-015-2874-z
Krüppel-like factor KLF10 deficiency predisposes to colitis through colonic macrophage dysregulation
American Journal of Physiology-Gastrointestinal and Liver Physiology
·
01 Dec 2015
·
doi:10.1152/ajpgi.00309.2015
Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation
Scientific Reports
·
30 Nov 2015
·
doi:10.1038/srep17549
IL17 Functions through the Novel REG3β–JAK2–STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer
Cancer Research
·
15 Nov 2015
·
doi:10.1158/0008-5472.CAN-15-0896
The Triple-Code Model for Pancreatic Cancer
Surgical Clinics of North America
·
01 Oct 2015
·
doi:10.1016/j.suc.2015.05.011
Erratum: Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes
Laboratory Investigation
·
01 Oct 2015
·
doi:10.1038/labinvest.2015.99
Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production
Journal of Clinical Investigation
·
14 Sep 2015
·
doi:10.1172/JCI79048
Functional Characterization of Nupr1L, A Novel p53‐Regulated Isoform of the High‐Mobility Group (HMG)‐Related Protumoral Protein Nupr1
Journal of Cellular Physiology
·
24 Aug 2015
·
doi:10.1002/jcp.25022
Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes
Endocrinology
·
06 Aug 2015
·
doi:10.1210/en.2015-1145
Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes
Laboratory Investigation
·
01 Jun 2015
·
doi:10.1038/labinvest.2015.51
The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage
BMC Developmental Biology
·
29 May 2015
·
doi:10.1186/s12861-015-0073-x
Krüppel-like factor KLF10 regulates transforming growth factor receptor II expression and TGF-β signaling in CD8+ T lymphocytes
American Journal of Physiology-Cell Physiology
·
01 Mar 2015
·
doi:10.1152/ajpcell.00262.2014
2014
Evidence Revealing Deregulation of The KLF11-Mao A Pathway in Association with Chronic Stress and Depressive Disorders
Neuropsychopharmacology
·
15 Dec 2014
·
doi:10.1038/npp.2014.321
IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation
Journal of Clinical Investigation
·
24 Sep 2014
·
doi:10.1172/JCI76037
Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
·
15 Sep 2014
·
doi:10.1152/ajpregu.00085.2014
Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins
Journal of Molecular Modeling
·
24 Jul 2014
·
doi:10.1007/s00894-014-2357-7
Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating KrasG12D-induced senescence
Cell Death & Differentiation
·
06 Jun 2014
·
doi:10.1038/cdd.2014.74
Single and combinatorial chromatin coupling events underlies the function of transcript factor krüppel-like factor 11 in the regulation of gene networks
BMC Molecular Biology
·
25 May 2014
·
doi:10.1186/1471-2199-15-10
Aurora-A Mitotic Kinase Induces Endocrine Resistance through Down-Regulation of ERα Expression in Initially ERα+ Breast Cancer Cells
PLoS ONE
·
09 May 2014
·
doi:10.1371/journal.pone.0096995
New Role for Kruppel-like Factor 14 as a Transcriptional Activator Involved in the Generation of Signaling Lipids
Journal of Biological Chemistry
·
01 May 2014
·
doi:10.1074/jbc.M113.544346
Diabetes-Causing Gene, Kruppel-Like Factor 11, Modulates the Antinociceptive Response of Chronic Ethanol Intake
Alcoholism: Clinical and Experimental Research
·
15 Jan 2014
·
doi:10.1111/acer.12258
Pancreatitis promotes oncogenic KrasG12D-induced pancreatic transformation through activation of Nupr1
Molecular & Cellular Oncology
·
01 Jan 2014
·
doi:10.4161/mco.29913
2013
Membrane-To-Nucleus Signaling Links Insulin-Like Growth Factor-1- and Stem Cell Factor-Activated Pathways
PLoS ONE
·
07 Oct 2013
·
doi:10.1371/journal.pone.0076822
Role for Krüppel-Like Transcription Factor 11 in Mesenchymal Cell Function and Fibrosis
PLoS ONE
·
17 Sep 2013
·
doi:10.1371/journal.pone.0075311
Genetic inactivation ofNupr1acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis
Gut
·
11 Sep 2013
·
doi:10.1136/gutjnl-2013-305221
Corrigendum to “Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis” [Cancer Lett. 328 (2) (2012) 212–221]
Cancer Letters
·
01 Aug 2013
·
doi:10.1016/j.canlet.2013.05.024
Functional impact of Aurora A-mediated phosphorylation of HP1γ at serine 83 during cell cycle progression
Epigenetics & Chromatin
·
05 Jul 2013
·
doi:10.1186/1756-8935-6-21
Krüppel-like Factor 11 Regulates the Expression of Metabolic Genes via an Evolutionarily Conserved Protein Interaction Domain Functionally Disrupted in Maturity Onset Diabetes of the Young
Journal of Biological Chemistry
·
01 Jun 2013
·
doi:10.1074/jbc.M112.434670
Epigenetics: A Promising Paradigm for Better Understanding and Managing Pain
The Journal of Pain
·
01 Jun 2013
·
doi:10.1016/j.jpain.2013.01.772
Novel role of VMP1 as modifier of the pancreatic tumor cell response to chemotherapeutic drugs
Journal of Cellular Physiology
·
25 May 2013
·
doi:10.1002/jcp.24343
A Novel Role of the Sp/KLF Transcription Factor KLF11 in Arresting Progression of Endometriosis
PLoS ONE
·
28 Mar 2013
·
doi:10.1371/journal.pone.0060165
Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression
Epigenetics & Chromatin
·
28 Feb 2013
·
doi:10.1186/1756-8935-6-3
NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells
Autophagy
·
09 Jan 2013
·
doi:10.4161/auto.22258
Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis
Cancer Letters
·
01 Jan 2013
·
doi:10.1016/j.canlet.2012.10.005
2012
Polycomb Antagonizes p300/CREB-binding Protein-associated Factor to Silence FOXP3 in a Kruppel-like Factor-dependent Manner
Journal of Biological Chemistry
·
01 Oct 2012
·
doi:10.1074/jbc.M111.325332
Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death
Clinical Cancer Research
·
30 Sep 2012
·
doi:10.1158/1078-0432.CCR-12-0026
Inhibition of Histone Deacetylation Potentiates the Evolution of Acquired Temozolomide Resistance Linked to MGMT Upregulation in Glioblastoma Xenografts
Clinical Cancer Research
·
30 Jul 2012
·
doi:10.1158/1078-0432.CCR-12-0560
Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer
EMBO Molecular Medicine
·
23 Jul 2012
·
doi:10.1002/emmm.201201255
Mechanistic Role for a Novel Glucocorticoid-KLF11 (TIEG2) Protein Pathway in Stress-induced Monoamine Oxidase A Expression
Journal of Biological Chemistry
·
01 Jul 2012
·
doi:10.1074/jbc.M112.373936
Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis
Journal of Clinical Investigation
·
01 Jun 2012
·
doi:10.1172/JCI60144
Sequence-specific Recruitment of Heterochromatin Protein 1 via Interaction with Krüppel-like Factor 11, a Human Transcription Factor Involved in Tumor Suppression and Metabolic Diseases
Journal of Biological Chemistry
·
01 Apr 2012
·
doi:10.1074/jbc.M112.342634
Krüppel-like Factor 11 Differentially Couples to Histone Acetyltransferase and Histone Methyltransferase Chromatin Remodeling Pathways to Transcriptionally Regulate Dopamine D2 Receptor in Neuronal Cells
Journal of Biological Chemistry
·
01 Apr 2012
·
doi:10.1074/jbc.M112.351395
Detailed Structural-Functional Analysis of the Krüppel-like Factor 16 (KLF16) Transcription Factor Reveals Novel Mechanisms for Silencing Sp/KLF Sites Involved in Metabolism and Endocrinology
Journal of Biological Chemistry
·
01 Mar 2012
·
doi:10.1074/jbc.M111.266007
2011
MAGE I Transcription Factors Regulate KAP1 and KRAB Domain Zinc Finger Transcription Factor Mediated Gene Repression
PLoS ONE
·
18 Aug 2011
·
doi:10.1371/journal.pone.0023747
Disruption of a Nuclear NFATc2 Protein Stabilization Loop Confers Breast and Pancreatic Cancer Growth Suppression by Zoledronic Acid
Journal of Biological Chemistry
·
01 Aug 2011
·
doi:10.1074/jbc.M110.197533
Disruption of a Novel Krüppel-like Transcription Factor p300-regulated Pathway for Insulin Biosynthesis Revealed by Studies of the c.-331 INS Mutation Found in Neonatal Diabetes Mellitus
Journal of Biological Chemistry
·
01 Aug 2011
·
doi:10.1074/jbc.M110.215822
Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis
Hepatology
·
01 Aug 2011
·
doi:10.1002/hep.24427
A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth
Biochemical Journal
·
29 Mar 2011
·
doi:10.1042/BJ20100773
A Team of Champions
Pancreatology
·
01 Mar 2011
·
doi:10.1159/000323211
Epigenetic Silencing of Tumor Suppressor Genes in Pancreatic Cancer
Journal of Gastrointestinal Cancer
·
12 Feb 2011
·
doi:10.1007/s12029-011-9256-2
2010
Pancreatic Stellate Cell Models for Transcriptional Studies of Desmoplasia-Associated Genes
Pancreatology
·
01 Oct 2010
·
doi:10.1159/000320540
2010-2011 Meetings and Conferences
Pancreatology
·
01 Oct 2010
·
doi:10.1159/000315009
Kitlow Stem Cells Cause Resistance to Kit/Platelet-Derived Growth Factor α Inhibitors in Murine Gastrointestinal Stromal Tumors
Gastroenterology
·
01 Sep 2010
·
doi:10.1053/j.gastro.2010.05.083
Combinatorial Chemoprevention Reveals a Novel Smoothened-Independent Role of GLI1 in Esophageal Carcinogenesis
Cancer Research
·
31 Aug 2010
·
doi:10.1158/0008-5472.CAN-10-0197
Angiogenesis
Pancreatology
·
01 Jun 2010
·
doi:10.1159/000297465
The Extracellular Matrix and Cell Migration
Pancreatology
·
01 Apr 2010
·
doi:10.1159/000280292
Distinct Role of Kruppel-like Factor 11 in the Regulation of Prostaglandin E2 Biosynthesis
Journal of Biological Chemistry
·
01 Apr 2010
·
doi:10.1074/jbc.M109.077065
Conservation of the TGFβ/Labial Homeobox Signaling Loop in Endoderm-Derived Cells between Drosophila and Mammals
Pancreatology
·
01 Apr 2010
·
doi:10.1159/000276895
2009
Microscopy
Pancreatology
·
01 Nov 2009
·
doi:10.1159/000219967
Sin3: Master scaffold and transcriptional corepressor
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
·
01 Jun 2009
·
doi:10.1016/j.bbagrm.2009.05.007
Funding Opportunities for Rare Pancreatic Diseases
Pancreatology
·
01 Jun 2009
·
doi:10.1159/000213442
Primers on Molecular Pathways —The Insulin Pathway
Pancreatology
·
01 May 2009
·
doi:10.1159/000200021
Diabetes
Pancreatology
·
01 May 2009
·
doi:10.1159/000187722
Silencing of the Transforming Growth Factor-β (TGFβ) Receptor II by Krüppel-like Factor 14 Underscores the Importance of a Negative Feedback Mechanism in TGFβ Signaling
Journal of Biological Chemistry
·
01 Mar 2009
·
doi:10.1074/jbc.M807791200
Primers on Molecular Pathways — Caspase Pathway
Pancreatology
·
01 Jan 2009
·
doi:10.1159/000178860
Lipid Biology
Pancreatology
·
01 Jan 2009
·
doi:10.1159/000235624
Krüppel-like Factor Proteins and Chromatin Dynamics
The Biology of Krüppel-like Factors
·
01 Jan 2009
·
doi:10.1007/978-4-431-87775-2_3
Educational Websites — Bioinformatics Tools II
Pancreatology
·
01 Jan 2009
·
doi:10.1159/000178767
2008
Primers on Molecular Pathways — Pain and Opioid Receptors, I
Pancreatology
·
01 Oct 2008
·
doi:10.1159/000159212
Patient Advocacy
Pancreatology
·
01 Oct 2008
·
doi:10.1159/000151478
Pain Management
Pancreatology
·
01 Oct 2008
·
doi:10.1159/000159211
The sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer research
Current Opinion in Gastroenterology
·
01 Sep 2008
·
doi:10.1097/MOG.0b013e32830b111d
Societies
Pancreatology
·
01 Jun 2008
·
doi:10.1159/000134270
Primers on Molecular Pathways — Notch
Pancreatology
·
01 May 2008
·
doi:10.1159/000123603
Microarray Databases I
Pancreatology
·
01 May 2008
·
doi:10.1159/000123602
Pharmacogenomics
Pancreatology
·
01 Apr 2008
·
doi:10.1159/000114645
2007
Epigenetics
Pancreatology
·
01 Oct 2007
·
doi:10.1159/000108954
Stem Cells
Pancreatology
·
01 Sep 2007
·
doi:10.1159/000105496
Alcohol and Pancreas
Pancreatology
·
01 Jul 2007
·
doi:10.1159/000103921
Laboratory Skills
Pancreatology
·
01 May 2007
·
doi:10.1159/000099002
2006
Animal models
Pancreatology
·
01 Oct 2006
·
doi:10.1159/000094559
Educational Websites — Signaling Pathways
Pancreatology
·
01 Aug 2006
·
doi:10.1159/000092686
Educational Websites - Cell Biology II
Pancreatology
·
01 Apr 2006
·
doi:10.1159/000090021
Evidence for the existence of an HP1-mediated subcode within the histone code
Nature Cell Biology
·
12 Mar 2006
·
doi:10.1038/ncb1383
[no title info]
Genome Biology
·
01 Jan 2006
·
doi:10.1186/gb-2006-7-7-228
2005
The family feud: turning off Sp1 by Sp1-like KLF proteins
Biochemical Journal
·
08 Nov 2005
·
doi:10.1042/BJ20051234
When developmental signaling pathways go wrong and their impact on pancreatic cancer development
Current Opinion in Gastroenterology
·
01 Sep 2005
·
doi:10.1097/01.mog.0000175462.38153.f7
Funding opportunities
Pancreatology
·
01 Jan 2005
·
doi:10.1159/000084536
Bioinformatics tools
Pancreatology
·
01 Jan 2005
·
doi:10.1159/000086531
2003
Expression profiling in pancreatic cancer research: the initial steps and the road ahead
Current Opinion in Gastroenterology
·
01 Sep 2003
·
doi:10.1097/00001574-200309000-00005
Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer
Genes, Chromosomes and Cancer
·
16 Jun 2003
·
doi:10.1002/gcc.10236
Characterization of the common fragile site FRA9E and its potential role in ovarian cancer
Oncogene
·
29 Jan 2003
·
doi:10.1038/sj.onc.1206171
1999
Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer
Genes, Chromosomes and Cancer
·
01 Jan 1999
·
doi:10.1002/(SICI)1098-2264(199901)24:1<48::AID-GCC7>3.0.CO;2-V